Publications

——————–2014——————–

  1. Fallah-Araghi A, Meguellati K, Baret JC, El Harrak A, Mangeat T, Karplus M, Ladame S, Marques CM, Griffiths A, Enhanced chemical synthesis at soft interfaces: A universal reaction-adsorption mechanism in microcompartments. Phys. Rev. Lett., 2014, Vol. 112, 028301.

  2. Sleiman MH, Ladame S, Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules. Chem. Commun., 2014, Vol.50, Pages: 5288-5290.

——————–2013——————–

  1. Meguellati K, Fallah-Araghi A, Baret JC, El Harrak A, Mangeat T, Marques C, Griffiths A, Ladame S, Enhanced imine synthesis in water: from surfactant-mediated catalysis to host-guest mechanisms. Chem. Commun., 2013, Vol. 49, Pages: 11332-1133.
  2. Najah M, Mayot E, Wijaya IP, Griffiths A, Ladame S, Drevelle A, New glycosidase substrates for droplet-based microfluidics screening. Anal. Chem., 2013, Vol. 85, Pages: 9807-9814.
  3. Percivalle C, Bartolo JF, Ladame S, Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process. Org. Biomol. Chem., 2013, Vol. 11, Pages:16-26.
  4. Percivalle C, Mahmood T, Ladame S, Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters. MedChemComm, 2013, Vol. 4, Pages: 211-215.

——————–2012——————–

  1. Mahmood T, Wu Y, Loriot D, Kuimova M, Ladame S, Closing the ring to bring up the light: synthesis of a hexacyclic acridinium cyanine dye. Chemistry Eur. J., 2012, Vol:18, Pages:12349-12356
  2. Meguellati K, Ladame S, Reversible covalent chemistries compatible with the principles of constitutional dynamic chemistry: new reactions to create more diversity., Top Curr Chem, 2012, Vol:322, Pages:291-314, ISSN:0340-1022

——————–2011——————–

  1. Meguellati K, Ladame S, Spichty M, A conceptually improved TD-DFT approach for predicting the maximum absorption wavelength of cyanine dyes, DYES AND PIGMENTS, 2011, Vol:90, Pages:114-118, ISSN:0143-7208

——————–2010——————–

  1. Koripelly G, Meguellati K, Ladame S, Dual sensing of hairpin and quadruplex DNA structures using multicolored peptide nucleic acid fluorescent probes., Bioconjug Chem, 2010, Vol:21, Pages:2103-2109
  2. Meguellati K, Spichty M, Ladame S, Synthesis, spectroscopic and DNA alkylating properties of malondialdehyde (MDA) bis-imine fluorescent adducts., Mol Biosyst, 2010, Vol:6, Pages:1694-1699
  3. Meguellati K, Koripelly G, Ladame S, DNA-templated synthesis of trimethine cyanine dyes: a versatile fluorogenic reaction for sensing G-quadruplex formation., Angew Chem Int Ed Engl, 2010, Vol:49, Pages:2738-2742
  4. Mahmood T, Paul A, Ladame S, Synthesis and spectroscopic and DNA-binding properties of fluorogenic acridine-containing cyanine dyes., J Org Chem, 2010, Vol:75, Pages:204-207

——————–2009——————–

  1. Paul A, Ladame S, 9-Amino acridines undergo reversible amine exchange reactions in water: implications on their mechanism of action in vivo., Org Lett, 2009, Vol:11, Pages:4894-4897
  2. Meguellati K, Spichty M, Ladame S, Reversible synthesis and characterization of dynamic imino analogues of trimethine and pentamethine cyanine dyes., Org Lett, 2009, Vol:11, Pages:1123-1126
  3. Redman JE, Granadino-Roldán JM, Schouten JA, et al, Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates., Org Biomol Chem, 2009, Vol:7, Pages:76-84

——————–2008——————–

  1. Soldatenkov VA, Vetcher AA, Duka T, et al, First evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1., ACS Chem Biol, 2008, Vol:3, Pages:214-219
  2. Ladame S, Dynamic combinatorial chemistry: on the road to fulfilling the promise., Org Biomol Chem, 2008, Vol:6, Pages:219-226, ISSN:1477-0520
  3. Paul A, Sengupta P, Krishnan Y, et al, Combining G-quadruplex targeting motifs on a single peptide nucleic acid scaffold: a hybrid (3+1) PNA-DNA bimolecular quadruplex., Chemistry, 2008, Vol:14, Pages:8682-8689, ISSN:0947-6539

——————–2007——————–

  1. Shirude PS, Gillies ER, Ladame S, et al, Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands., J Am Chem Soc, 2007, Vol:129, Pages:11890-11891, ISSN:0002-7863
  2. Shirude PS, Gillies E, Ladame S, et al, ORGN 41-Quinoline oligoamide macrocycle: Selective G quadruplex binding ligand, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, Vol:234, ISSN:0065-7727

——————–2006——————–

  1. Redman JE, Ladame S, Reszka AP, et al, Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library., Org Biomol Chem, 2006, Vol:4, Pages:4364-4369, ISSN:1477-0520
  2. Jantos K, Rodriguez R, Ladame S, et al, Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands., J Am Chem Soc, 2006, Vol:128, Pages:13662-13663, ISSN:0002-7863
  3. Gonçalves DP, Ladame S, Balasubramanian S, et al, Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins., Org Biomol Chem, 2006, Vol:4, Pages:3337-3342, ISSN:1477-0520
  4. Green JJ, Ladame S, Ying L, et al, Investigating a quadruplex-ligand interaction by unfolding kinetics, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, Vol:128, Pages:9809-9812, ISSN:0002-7863
  5. Fernando H, Reszka AP, Huppert J, et al, A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene., Biochemistry, 2006, Vol:45, Pages:7854-7860, ISSN:0006-2960
  6. Ladame S, Schouten JA, Roldan J, et al, Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein., Biochemistry, 2006, Vol:45, Pages:1393-1399, ISSN:0006-2960

——————–2005——————–

  1. Azéma L, Ladame S, Lapeyre C, et al, Does phosphoryl protonation occurs in aqueous phosphoesters solutions., Spectrochim Acta A Mol Biomol Spectrosc, 2005, Vol:62, Pages:287-292, ISSN:1386-1425
  2. Ladame S, Whitney AM, Balasubramanian S, Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach., Angew Chem Int Ed Engl, 2005, Vol:44, Pages:5736-5739, ISSN:1433-7851
  3. Rankin S, Reszka AP, Huppert J, et al, Putative DNA quadruplex formation within the human c-kit oncogene., J Am Chem Soc, 2005, Vol:127, Pages:10584-10589, ISSN:0002-7863
  4. Ladame S, Fauré R, Denier C, et al, Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues., Org Biomol Chem, 2005, Vol:3, Pages:2070-2072, ISSN:1477-0520

——————–2004——————–

  1. Patel SD, Isalan M, Gavory G, et al, Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes., Biochemistry, 2004, Vol:43, Pages:13452-13458, ISSN:0006-2960
  2. Ladame S, Schouten JA, Stuart J, et al, Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform., Org Biomol Chem, 2004, Vol:2, Pages:2925-2931, ISSN:1477-0520
  3. Whitney AM, Ladame S, Balasubramanian S, Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry., Angew Chem Int Ed Engl, 2004, Vol:43, Pages:1143-1146, ISSN:1433-7851

——————–2003——————–

  1. Ladame S, Castilho MS, Silva CH, et al, Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-d-glyceric acid., Eur J Biochem, 2003, Vol:270, Pages:4574-4586, ISSN:0014-2956
  2. Ladame S, Castilho MS, Silva CHTP, et al, Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid – Selective inhibition by structure-based design, EUROPEAN JOURNAL OF BIOCHEMISTRY, 2003, Vol:270, Pages:4574-4586, ISSN:0014-2956
  3. Castilho MS, Pavão F, Oliva G, et al, Evidence for the two phosphate binding sites of an analogue of the thioacyl intermediate for the Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase-catalyzed reaction, from its crystal structure., Biochemistry, 2003, Vol:42, Pages:7143-7151, ISSN:0006-2960
  4. Schouten JA, Ladame S, Mason SJ, et al, G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection., J Am Chem Soc, 2003, Vol:125, Pages:5594-5595, ISSN:0002-7863

——————–2002——————–

  1. Ladame S, Willson M, Perie J, A convenient synthesis of dibenzyl alpha,alpha-difluoromethyl-beta-ketophosphonates, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2002, Pages:2640-2648, ISSN:1434-193X
  2. Ladame S, Harrison RJ, Neidle S, et al, Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates., Org Lett, 2002, Vol:4, Pages:2509-2512, ISSN:1523-7060

——————–2001——————–

  1. Ladame S, Bardet M, Périé J, et al, Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues., Bioorg Med Chem, 2001, Vol:9, Pages:773-783, ISSN:0968-0896
  2. Ladame S, Claustre S, Willson M, Selective phosphorylation on primary alcohols of unprotected polyols, PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2001, Vol:174, Pages:37-47, ISSN:1042-6507